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Beyond their established role as energy substrates, SCFAs act as localized and systemic signaling molecules through G protein-coupled receptors (GPR41, GPR43, and GPR109A), thereby mediating bidirectional communication between the gastrointestinal tract and peripheral organs 165

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It was found that pregnant mice exposed to APAP showed signs of liver toxicity, affected immune adaptation to pregnancy, harm to placental functional regions, decreased maternal progesterone, hindered fetal development, lower fetal weight, and decreased T-cell development